Related Experiment Video
Updated: Mar 18, 2026

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
Published on: July 20, 2016
Baseline renal function as a prognostic indicator in patients with newly diagnosed diffuse large B-cell lymphoma
Junshik Hong1, Sojung Lee1, Gayoung Chun1
1Department of Internal Medicine, Gachon University Gil Medical Center Incheon Regional Cancer Center, Gachon University College of Medicine, Incheon, Korea.
Baseline renal impairment (RI) is an independent predictor of poorer outcomes in diffuse large B-cell lymphoma (DLBCL) patients receiving R-CHOP21 chemotherapy. This finding highlights the importance of assessing kidney function for prognosis in DLBCL.
Area of Science:
- Oncology
- Nephrology
- Hematology
Background:
- The prognostic impact of baseline renal impairment (RI) in diffuse large B-cell lymphoma (DLBCL) remains undefined.
- Rituximab plus cyclophosphamide, Adriamycin, vincristine, and prednisolone (R-CHOP21) is a standard immunochemotherapy for DLBCL.
Purpose of the Study:
- To determine the prognostic value of baseline renal impairment (RI) in DLBCL patients treated with R-CHOP21.
- To investigate RI as an independent prognostic factor in DLBCL.
Main Methods:
- Retrospective analysis of 185 newly diagnosed DLBCL patients treated with R-CHOP21.
- Glomerular filtration rate (GFR) calculated using the CKD-EPI formula to define RI (GFR <60 mL/min/1.73 m²).
Main Results:
- 10.3% of patients (19/185) presented with baseline RI.
- Patients with baseline RI had significantly inferior overall survival (OS) (P<0.001).
- RI was an International Prognostic Index (IPI)-independent prognostic indicator, particularly when combined with low hemoglobin levels.
Conclusions:
- Pretreatment renal impairment is an independent prognostic marker for inferior OS in DLBCL patients receiving R-CHOP21.
- Assessing baseline kidney function is crucial for risk stratification in DLBCL patients undergoing R-CHOP21 therapy.
More Related Videos
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
09:43Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Related Concept Videos
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Serum Studies: Renal Function Tests
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance