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Related Experiment Video

Updated: Mar 18, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses
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[Intraocular Pressure Sensor Based on a Contact Lens].

Xuhong Guo, Weihua Pet, Zhaolin Yao

    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
    |July 8, 2016
    PubMed
    Summary

    This study presents a novel, wearable intraocular pressure (IOP) sensor integrated into a contact lens. This noninvasive device offers continuous IOP monitoring, crucial for glaucoma management and eye health.

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    Area of Science:

    • Biomedical Engineering
    • Ophthalmology
    • Materials Science

    Background:

    • Intraocular pressure (IOP) monitoring is vital for eye health and glaucoma management.
    • Traditional IOP measurement methods are hospital-based, time-consuming, and lack continuous monitoring capabilities.
    • A noninvasive, wearable solution for continuous IOP detection is needed.

    Purpose of the Study:

    • To develop and evaluate a microminiaturized intraocular pressure sensor embedded in a soft contact lens.
    • To enable convenient, comfortable, and noninvasive 24-hour continuous IOP monitoring.
    • To correlate changes in corneal curvature measured by the sensor to variations in intraocular pressure.

    Main Methods:

    • Fabrication of a micro-electro-mechanical systems (MEMS) strain gauge.
    • Integration of the strain gauge into a polydimethylsiloxane (PDMS) soft contact lens using injection molding.
    • Experimental validation of sensor performance and sensitivity.

    Main Results:

    • The fabricated strain gauge achieved a sensitivity of 100.7 µV/µm.
    • The integrated contact lens sensor demonstrated an average sensitivity of 125.8 µV/mm Hg for intraocular pressure detection under ideal conditions.
    • The sensor allows for noninvasive measurement of corneal curvature changes correlated with IOP.

    Conclusions:

    • A novel MEMS strain gauge integrated into a PDMS contact lens enables noninvasive intraocular pressure monitoring.
    • This wearable sensor technology offers a promising solution for continuous, convenient IOP assessment.
    • The developed sensor has significant potential for early detection and management of glaucoma and other eye conditions.