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A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
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[Research on Cardiac Structure and Function in the Overweight and Obese population and Influence Factors]

Yanmei Zhang, Lina Han, He Huang

    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
    |July 8, 2016
    PubMed

    Insights

    Cardiac function is impaired in overweight and obese individuals, with decreased strain and altered diastolic function. Body Mass Index (BMI), waist-to-hip ratio (WHR), and free fatty acids (FFA) are key influencing factors.

    Area of Science:

    • Cardiology
    • Medical Imaging
    • Obesity Research

    Background:

    • Overweight and obesity are associated with cardiovascular complications.
    • Early detection of cardiac dysfunction in these populations is crucial.

    Purpose of the Study:

    • To investigate cardiac structure and function in healthy, overweight, and obese individuals.
    • To identify correlations between obesity indices and cardiac parameters.

    Main Methods:

    • Tissue Doppler Imaging (TDI), 2D speckle tracking imaging (2D-STI), and 3D speckle tracking imaging (3D-STI) were used.
    • Analysis included global longitudinal strain (GLS), global circumferential strain (GCS), global area strain (GAS), and global radial strain (GRS).
    • Correlations with Body Mass Index (BMI), Waist to Hip Ratio (WHR), and Free Fatty Acid (FFA) were assessed.

    Main Results:

    • Overweight and obese groups showed progressive decreases in GLS, GCS, GAS, and GRS compared to healthy individuals.
    • Cardiac strain parameters and E/e'sr were significantly correlated with BMI and FFA.
    • BMI, WHR, and FFA were identified as independent factors influencing cardiac function.

    Conclusions:

    • Cardiac structure is altered, and left ventricular systolic and diastolic function are impaired in overweight and obese populations.
    • BMI, WHR, and FFA are significant independent predictors of cardiac dysfunction in this demographic.

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