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[Progress in developing and applying Streptomyces chassis - A review].

Liping Xiao, Zixin Deng, Tiangang Liu

    Wei Sheng Wu Xue Bao = Acta Microbiologica Sinica
    |July 8, 2016
    PubMed
    Summary
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    Synthetic biology enables heterologous expression of natural products using Streptomyces chassis. This approach overcomes challenges in natural product synthesis and bacterial cultivation for drug discovery.

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    Area of Science:

    • Biotechnology and Synthetic Biology
    • Microbiology
    • Natural Products Chemistry

    Context:

    • Natural products are vital in healthcare, but their synthesis is challenging.
    • Many natural product-producing bacteria have cultivation and productivity limitations.
    • Silent gene clusters hinder secondary metabolite discovery in native strains.

    Purpose:

    • To review strategies for developing Streptomyces as heterologous expression chassis.
    • To highlight the significance of Streptomyces in natural product biosynthesis.
    • To showcase practical applications of Streptomyces chassis in synthetic biology.

    Summary:

    • This review focuses on using Streptomyces as chassis cells for heterologous expression of natural products.
    • It details the development strategies and current status of Streptomyces chassis.
    • Examples illustrate the application of various Streptomyces chassis for producing valuable compounds.

    Impact:

    • Facilitates the discovery and production of novel drug entities.
    • Overcomes technical and cost barriers in natural product synthesis.
    • Enables the exploitation of silent gene clusters for new metabolite generation.