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Updated: Mar 18, 2026

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
Published on: July 6, 2016
Highly solvatochromic and tunable fluorophores based on a 4,5-quinolimide scaffold: novel CDK5 probes
Juan A González-Vera1, Francisco Fueyo-González, Ibon Alkorta
1Instituto de Química Médica (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. rosario@iqm.csic.es.
Abstract:
Novel 4,5-quinolimide-based fluorophores are more solvatochromic and red-shifted than known naphthalimide analogues. Conjugation of one of these fluorophores to a peptide derived from CDK5 kinase demonstrated its sensitivity for monitoring the interaction with its regulatory partner p25. Introduction of the quinolimide-labelled peptide into living glioblastoma cells probed the interaction with endogenous p25.
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