Nutraceutical therapies for atherosclerosis

Area of Science:

• Cardiovascular Science
• Nutritional Science
• Pharmacology

Background:

• Atherosclerosis is a chronic inflammatory arterial disease and a primary cause of cardiovascular disease (CVD).
• Despite advances in pharmacotherapy, CVD remains a leading global cause of mortality, accounting for one-third of all deaths.
• Nutraceuticals offer a potential therapeutic strategy for atherosclerosis due to their disease-preventive and treatment benefits.

Purpose of the Study:

• To review potential nutraceuticals for antiatherogenic therapy.
• To evaluate in vitro and in vivo evidence supporting nutraceutical efficacy.
• To discuss human clinical and observational study findings on nutraceuticals in atherosclerosis prevention.

Main Methods:

• Literature review of in vitro and in vivo studies on nutraceuticals.
• Analysis of observational human studies.
• Evaluation of randomized clinical trials in humans.

Main Results:

• Evidence from preclinical studies suggests specific nutraceuticals possess antiatherogenic properties.
• Observational data indicates a potential role for certain nutraceuticals in preventing atherosclerosis.
• Clinical trial results provide insights into the human efficacy of nutraceutical interventions.

Conclusions:

• Nutraceuticals represent a promising therapeutic avenue for managing atherosclerosis.
• Further research and clinical validation are essential to fully establish the role of nutraceuticals in CVD prevention.
• Integrating nutraceuticals into therapeutic strategies may help reduce the global burden of cardiovascular disease.