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Updated: Mar 18, 2026
Production of Human Norovirus Protruding Domains in E. coli for X-ray Crystallography
Published on: April 19, 2016
Synthesis and Evaluation of Biotinylated Bivalent HistoBlood Group Antigens for Capturing Human Noroviruses
Abasaheb N Dhawane1, Marta Diez-Valcarce2, Bharat P Gurale1
1788 Petit Science Center, Department of Chemistry, Georgia State University , Atlanta, Georgia 30302-4098, United States.
Abstract:
A panel of biotinylated bivalent H-type glycans that have been reported as binding ligands for human noroviruses were synthesized using a modular synthetic strategy. These glycoconjugates were attached to streptavidin-coated magnetic beads and used to recover human norovirus from fecal samples using a magnetic bead-based assay. The biotinylated bivalent glycans synthesized for this study exhibited similar or better capturing ability when compared to commercial biotinylated glycopolymers.
