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Related Concept Videos

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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Adaptive Mechanisms in Cancer Cells02:53

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Cancer02:18

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Related Experiment Video

Updated: Mar 18, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
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A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

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Inflammatory fibroblasts in cancer.

Hyesol Lim1, Aree Moon2

  • 1Duksung Innovative Drug Center, College of Pharmacy, Duksung Women's University, Seoul, 132-714, Korea.

Archives of Pharmacal Research
|July 8, 2016
PubMed
Summary

Inflammation fuels cancer progression by altering the tumor microenvironment. Cancer-associated fibroblasts (CAFs) promote tumor growth, invasion, and metastasis through inflammatory signaling, impacting cancer treatment strategies.

Keywords:
Cancer-associated fibroblasts (CAFs)Epithelial–mesenchymal transition (EMT)FibroblastsTumor microenvironment

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Experimental Generation of Carcinoma-Associated Fibroblasts CAFs from Human Mammary Fibroblasts
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Isolation of Normal and Cancer-associated Fibroblasts from Fresh Tissues by Fluorescence Activated Cell Sorting FACS
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Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • The tumor microenvironment, comprising fibroblasts, immune cells, and extracellular matrix, significantly influences cancer progression.
  • Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment, implicated in tumor growth, invasion, and metastasis.
  • Inflammation is intrinsically linked to cancer development and progression, with inflammatory cells playing a critical role.

Purpose of the Study:

  • To review the intricate relationships between fibroblasts, inflammatory responses, the tumor microenvironment, and cancer progression.
  • To elucidate the role of cancer-associated fibroblasts (CAFs) in mediating tumor-promoting inflammation.
  • To highlight the importance of understanding these interactions for developing novel cancer therapies.

Main Methods:

  • Literature review synthesizing existing research on inflammation, tumor microenvironment, and cancer.
  • Analysis of the mechanisms by which fibroblasts, particularly CAFs, influence cancer progression.
  • Examination of the role of epithelial-mesenchymal transition in cancer metastasis, with a focus on fibroblast involvement.

Main Results:

  • CAFs are identified as critical mediators of tumor-promoting inflammation within the tumor microenvironment.
  • Fibroblasts, especially CAFs, significantly contribute to cancer cell invasion and metastasis.
  • The tumor microenvironment's inflammatory state is crucial for tumor growth, survival, and dissemination.

Conclusions:

  • Targeting inflammatory responses within the tumor microenvironment presents a promising therapeutic strategy for cancer prevention and treatment.
  • Understanding the multifaceted roles of fibroblasts and inflammation is essential for advancing oncology.
  • Further research into CAFs and their signaling pathways can lead to more effective cancer therapies.