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Updated: Mar 18, 2026

Guidelines and Experience Using Imaging Biomarker Explorer IBEX for Radiomics
Published on: January 8, 2018
R Ruiz-Cruces1, E Vano2, F Carrera-Magariño3
1School of Medicine, University of Malaga, Malaga, Spain. rrcmf@uma.es.
This study established national radiation dose benchmarks for common interventional radiology procedures in Spain. By categorizing procedures based on their technical difficulty, researchers demonstrated that patient radiation exposure varies significantly depending on the specific task performed. These findings help hospitals better monitor and optimize radiation safety for patients.
Area of Science:
Background:
Radiation exposure during medical imaging requires careful monitoring to ensure patient safety. No prior work had resolved the specific dose benchmarks for diverse interventional procedures across Spanish healthcare facilities. That uncertainty drove the need for standardized metrics. Prior research has shown that procedural difficulty significantly influences the total radiation delivered to patients. However, existing guidelines often lack the nuance required for complex surgical interventions. This gap motivated the development of a national framework to track radiation metrics. Researchers recognized that simple dose averages fail to reflect the technical demands of specific clinical tasks. Establishing clear reference points allows for better comparison between different medical centers.
Purpose Of The Study:
The primary aim of this study is to propose national diagnostic reference levels for interventional radiology procedures. Researchers sought to evaluate how procedural complexity influences the radiation doses delivered to patients. This project addresses the lack of standardized benchmarks for complex medical interventions in Spanish hospitals. The team focused on identifying how technical difficulty correlates with variations in radiation exposure metrics. By establishing these reference points, the authors intend to improve radiation safety standards across the country. The study addresses the need for a systematic framework to guide clinical audits in radiology departments. Investigators aimed to provide clear criteria for hospitals to monitor and optimize their imaging practices. This work serves to bridge the gap between general dose guidelines and the specific demands of complex surgical tasks.
Main Methods:
The research team coordinated with eight distinct hospital units to collect data on patient radiation exposure. Review approach involved gathering Kerma area product values from a total of 1,649 individual procedures. Participants implemented uniform quality control protocols for all X-ray equipment involved in the study. A consensus document provided the framework for classifying the difficulty of seven specific clinical interventions. Investigators calculated the 3rd quartile of exposure values to establish national benchmarks for each procedure type. The team analyzed how technical demands correlate with variations in radiation output. This systematic approach allowed for the comparison of dose metrics across different medical facilities. Researchers ensured that all participating centers followed standardized reporting procedures throughout the project duration.
Main Results:
Key findings from the literature indicate that radiation doses vary widely based on the specific type of interventional procedure performed. The 3rd quartile Kerma area product values ranged from 30 Gy cm2 for biliary drainage to 303 Gy cm2 for hepatic chemoembolization. Hepatic chemoembolization recorded the highest dose, while biliary drainage required the lowest radiation exposure. Other procedures like iliac stent and colon endoprostheses showed values of 170 Gy cm2 and 169 Gy cm2, respectively. The analysis revealed that procedural complexity significantly drives radiation increases, with biliary drainage showing a thirteen-fold rise. Hepatic chemoembolization and femoropopliteal revascularization both demonstrated a five-fold increase in radiation factors. Transjugular hepatic biopsies exhibited a four-fold increase in dose requirements compared to simpler tasks. Uterine fibroid embolization and colon endoprostheses both showed a three-fold increase in radiation exposure metrics.
Conclusions:
The researchers propose that national benchmarks for radiation exposure must incorporate procedural difficulty levels. Clinical audits should integrate these complexity factors to ensure accurate assessment of radiation safety. Synthesis and implications suggest that simple dose monitoring is insufficient for complex interventional tasks. Future quality control efforts should prioritize the categorization of procedures by their technical requirements. Standardized metrics provide a robust foundation for optimizing radiation protection in clinical settings. The authors emphasize that accounting for task difficulty improves the utility of diagnostic reference levels. Consistent application of these criteria supports safer practices across diverse hospital environments. These findings demonstrate that radiation management strategies require a multi-faceted approach to be effective.
The researchers propose that diagnostic reference levels are calculated as the 3rd quartile of Kerma area product values. This statistical approach provides a benchmark for radiation exposure across various interventional procedures, allowing clinicians to compare their local performance against national standards.
The study utilized Kerma area product, measured in Gy cm2, as the primary metric for quantifying patient radiation exposure. This specific unit captures the total energy delivered to the patient during the imaging process, facilitating consistent comparisons across different clinical sites.
The authors state that evaluating procedural complexity is necessary because radiation doses vary significantly between simple and difficult tasks. By categorizing seven types of interventions, the team ensures that dose comparisons remain meaningful rather than misleading.
The consensus document serves as the foundational tool for establishing criteria to classify the difficulty of seven distinct interventional procedures. This framework enables researchers to standardize how different hospitals report and interpret their radiation data.
The researchers measured the impact of complexity by calculating the increase in Kerma area product factors, which ranged from three-fold to thirteen-fold. For example, biliary drainage showed a thirteen-fold increase, while uterine fibroid embolization and colon endoprostheses both exhibited a three-fold increase.
The authors suggest that integrating complexity levels into clinical audits will facilitate the optimization of radiation protection. This approach ensures that hospitals can identify areas for improvement while maintaining high standards of patient care during interventional radiology.