Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

4.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.2K
Lineage Commitment01:21

Lineage Commitment

4.5K
Commitment is the  process whereby stem cells:
4.5K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

17.0K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
17.0K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

9.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polyclonal evolution of lymphoproliferative disorders in XLP1.

Journal of human immunity·2026
Same author

BCL11B enhancer hijacking by t(14;16)(q32;q24) translocation defines a novel high-risk subtype of T-ALL.

Blood·2026
Same author

Functional impact of a deep intronic variant in the RPS19 gene detected in a case of Diamond-Blackfan anemia syndrome.

Haematologica·2026
Same author

Biological Features of KLC2 Mutations in Chronic Myeloid Leukemia and Their Contribution to Inducing Drug Resistance.

Oncology research·2026
Same author

Comprehensive molecular and functional analysis of NUTM1-rearranged leukemia.

Blood·2025
Same author

Somatic mutations and clonal evolution in normal tissues and cancer development.

Experimental & molecular medicine·2025

Related Experiment Video

Updated: Mar 18, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

10.2K

Clonal evolution in myelodysplastic syndromes.

Kenichi Yoshida1

  • 1Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|July 8, 2016
PubMed
Summary
This summary is machine-generated.

Recent advances in genome-wide analysis, particularly next-generation sequencing (NGS), have significantly improved understanding of myelodysplastic syndromes (MDS) pathogenesis. These studies reveal key genetic alterations in DNA methylation, RNA splicing, and cohesin pathways, alongside clonal evolution and germline mutation impacts.

More Related Videos

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

2.0K
Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
12:05

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

12.5K

Related Experiment Videos

Last Updated: Mar 18, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

10.2K
Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

2.0K
Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
12:05

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

12.5K

Area of Science:

  • Genomics
  • Hematology
  • Cancer Biology

Background:

  • Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders.
  • Understanding the genetic basis of MDS is crucial for improving diagnosis and treatment.
  • Advances in genomic technologies have revolutionized the study of MDS pathogenesis.

Purpose of the Study:

  • To review the significant genetic alterations identified in MDS over the past decade.
  • To highlight the role of novel technologies like SNP array karyotyping and next-generation sequencing (NGS).
  • To elucidate the impact of these genetic changes on MDS development, progression, and patient outcomes.

Main Methods:

  • Genome-wide analysis including single nucleotide polymorphism (SNP) array karyotyping.
  • Next-generation sequencing (NGS) for comprehensive genetic profiling.
  • Analysis of genetic alterations in key functional pathways and germline mutations.

Main Results:

  • Frequent genetic alterations identified in DNA methylation, RNA splicing, and cohesin complex formation pathways in MDS.
  • NGS has provided insights into the clonal evolution of MDS from pre-cancerous lesions.
  • Germline mutations have been shown to play a role in MDS development.

Conclusions:

  • Genome-wide analyses have substantially advanced the understanding of MDS pathogenesis.
  • NGS is a powerful tool for dissecting the genetic complexity and clonal heterogeneity of MDS.
  • Further research into these genetic alterations may lead to targeted therapies for MDS.