Immunotherapy for opportunistic infections: Current status and future perspectives

Area of Science:

• Immunology
• Hematology
• Infectious Diseases

Background:

• Allogeneic haematopoietic stem cell transplantation (allo-HSCT) outcomes have improved, but opportunistic infections remain a significant challenge.
• Viral and mold infections are major obstacles to successful cure after allo-HSCT.
• Adoptive T cell therapy presents a promising strategy to address these infections.

Purpose of the Study:

• To summarize current knowledge on adoptive T cell therapy for viral and mold infections post-allo-HSCT.
• To highlight advancements in the development and manufacturing of pathogen-specific T cells.

Main Methods:

• Review of current literature on adoptive T cell therapy.
• Focus on T cell products developed under good manufacturing practice (GMP) guidelines.
• Analysis of therapeutic strategies against viral and mold pathogens.

Main Results:

• Sophisticated techniques for developing pathogen-specific T cell products are now GMP-compliant.
• Adoptive T cell therapy is an emerging and viable treatment option.
• This therapy targets specific viral and mold pathogens.

Conclusions:

• Adoptive T cell therapy holds significant potential for improving outcomes in allo-HSCT patients.
• GMP-compliant T cell therapies are crucial for clinical application.
• Further research and application of T cell therapies are warranted to overcome infectious complications.