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Tissue Engineering in Orthopaedics.

Alexander M Tatara1, Antonios G Mikos2

  • 1Departments of Bioengineering (A.M.T. and A.G.M.) and Chemical and Biomolecular Engineering (A.G.M.), Rice University, Houston, Texas tatara@rice.edu.

The Journal of Bone and Joint Surgery. American Volume
|July 8, 2016
PubMed
Summary
This summary is machine-generated.

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Selecting the right scaffold, signals, and cells is crucial for orthopaedic tissue engineering. Clinical studies offer valuable lessons, but regulatory and economic hurdles remain for lab-to-clinic translation.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Orthopaedic Surgery

Background:

  • Tissue engineering for orthopaedic conditions requires careful selection of biomaterials, biochemical cues, and cellular components.
  • Clinical translation of tissue engineering strategies in orthopaedics faces significant challenges despite basic science advancements.

Purpose of the Study:

  • To highlight the critical factors in designing effective orthopaedic tissue engineering solutions.
  • To review lessons learned from existing clinical applications of tissue engineering in orthopaedics.
  • To identify barriers hindering the translation of tissue engineering technologies from research to clinical practice.

Main Methods:

  • Review of current literature on orthopaedic tissue engineering.

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  • Analysis of clinical case studies and outcomes.
  • Identification of key components: scaffolds, signaling molecules, and cell sources.
  • Examination of regulatory, economic, and clinical translation challenges.

    • Main Results:

    • Optimal combination of scaffold, signals, and cell types is essential for successful orthopaedic tissue engineering.
    • Limited but informative clinical studies provide insights into practical applications and challenges.
    • Significant regulatory, economic, and clinical hurdles impede the consistent translation of tissue engineering innovations.

    Conclusions:

    • Careful consideration of scaffold, signals, and cell types is paramount for orthopaedic tissue engineering success.
    • Clinical data, though scarce, offers crucial lessons for refining therapeutic strategies.
    • Overcoming translational barriers is vital to bridge the gap between laboratory discoveries and operating room applications in orthopaedics.