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Micronucleus frequencies in groups receiving external or internal radiation
Ayşegül Özdal1, Taner Erselcan2, Öztürk Özdemir3
1Department of Nuclear Medicine, Kayseri Training and Research Hospital, Kayseri 38010, Turkey.
Summary
Micronucleus (MN) frequency analysis can detect chromosome damage from internal and external radiation exposure. Radiation therapy patients showed the highest MN frequencies, indicating significant cellular impact.
Area of Science:
- Radiation biology
- Cytogenetics
- Medical physics
Background:
- Ionizing radiation exposure from medical treatments can induce chromosomal damage.
- Micronucleus (MN) frequency is a biomarker for genotoxicity.
- Assessing MN frequencies helps evaluate radiation-induced damage.
Purpose of the Study:
- To investigate alterations in micronucleus (MN) frequencies before and after internal and external ionizing radiation exposure.
- To compare MN frequencies across different radiation treatment modalities.
Main Methods:
- The study included 67 patients undergoing hyperthyroidism treatment, low-dose I-131 scanning, high-dose I-131 ablative therapy, or external radiotherapy.
- Micronucleus (MN) frequencies were analyzed pre- and post-treatment.
- Statistical analysis compared MN frequencies between patient groups.
Main Results:
- Micronucleus (MN) frequencies varied significantly (P < 0.05) between pre- and post-treatment assessments in all patient groups.
- Patients receiving external radiotherapy exhibited the highest post-treatment MN frequencies.
- Patients undergoing low-dose I-131 screening showed the lowest MN frequencies.
Conclusions:
- Micronucleus (MN) analysis is a valuable tool for assessing radiation-induced chromosome damage.
- The study highlights differential genotoxic effects of various internal and external radiation exposures.
- Findings support the utility of MN assays in monitoring patients exposed to medical radiation.
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