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Subcortical cerebral infarctions in sickle cell trait.

¹Division of Pathology (Neuropathology), Hektoen Institute for Medical Research, Cook County Hospital, Chicago, Illinois 60612.

Journal of Neurology, Neurosurgery, and Psychiatry

|April 1, 1989

Summary

Sickle cell trait can cause deep brain infarctions, leading to severe neurological issues like motor and visual deficits. Unusual neurological symptoms in sickle cell trait patients may indicate subcortical infarctions.

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Area of Science:

Neurology
Hematology
Pathology

Background:

Sickle cell trait (SCT) is a common genetic condition.
Neurological complications in SCT are typically associated with sickle cell disease.
Subcortical infarctions are rarely linked to sickle cell trait.

Observation:

Two patients with sickle cell trait presented with progressive neurological decline.
Autopsy revealed deep cerebral white matter and brain stem infarctions.
These findings align with a previously reported case in the literature.

Findings:

Subcortical infarctions may be an underrecognized complication of sickle cell trait.
The observed infarctions affected critical brain regions, correlating with clinical deficits.
A pattern suggests SCT can predispose individuals to specific cerebrovascular events.

Implications:

Clinicians should consider subcortical infarctions in the differential diagnosis for unusual neurological presentations in SCT patients.
Increased awareness may lead to earlier diagnosis and management of SCT-related neurological complications.
Further research is warranted to elucidate the pathophysiology and prevalence of these infarctions in SCT.

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