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Related Experiment Video

Updated: Mar 18, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

Eosinophilic bioactivities in severe asthma.

Tara F Carr¹, Sergejs Berdnikovs², Hans-Uwe Simon³

¹University of Arizona, Tucson, Arizona USA.

The World Allergy Organization Journal

|July 8, 2016

Summary

Eosinophils in asthma are linked to severe disease and treatment resistance. Identifying eosinophil biomarkers could personalize biotherapeutic strategies for better asthma management.

Keywords:

Bioactivities Biotherapeutics Eosinophilia Eosinophils Severe asthma

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Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Area of Science:

Immunology
Pulmonology
Cell Biology

Background:

Asthma is associated with eosinophilia, increasing disease severity and risk.
Eosinophils play a key role in immune responses and inflammation via mediator release.
Eosinophils can persist despite standard asthma treatments.

Purpose of the Study:

To review eosinophil effector mechanisms, markers, and outcomes in asthma.
To explore the potential of eosinophils as biomarkers for biotherapeutic response.
To inform personalized treatment strategies for severe asthma.

Main Methods:

Literature review of eosinophil function in asthma.
Analysis of eosinophil surface markers and clinical correlations.
Examination of eosinophil-targeted therapies and biomarker potential.

Main Results:

Eosinophil activity contributes significantly to asthma pathophysiology.
Eosinophil persistence is observed even with guideline-based therapies.
Eosinophils and their products show promise as predictive biomarkers.

Conclusions:

Understanding eosinophil roles is crucial for severe asthma management.
Eosinophil biomarkers can guide selection of patients for biotherapeutics.
Personalized medicine approaches targeting eosinophils offer therapeutic potential.