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2014 Jeffrey M. Hoeg Award Lecture: Transcriptional Control of Monocyte Development
Yanfang Peipei Zhu1, Graham D Thomas1, Catherine C Hedrick2
1From the Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA.
Insights
Transcription factors controlling monocyte development in bone marrow are crucial for atherosclerosis. Understanding these factors offers therapeutic targets to manage immune cell numbers and functions in disease.
Area of Science:
- Immunology
- Cell Biology
- Molecular Biology
Background:
- Monocytes and macrophages are pivotal immune cells implicated in the initial stages of atherosclerosis.
- Transcription factors governing monocyte development in the bone marrow are critical targets for therapeutic intervention.
- Modulating these transcription factors can influence the quantity and activity of monocytes and macrophages in disease contexts.
Abstract:
Monocytes and macrophages are key immune cells involved in the early progression of atherosclerosis. Transcription factors that control their development in the bone marrow are important therapeutic targets to control the numbers and functions of these cells in disease. This review highlights what is currently known about the transcription factors that are critical for monocyte development.
