![Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F3777.jpg&w=3840&q=50)
Vascular Inflammation Evaluated by [18F]-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Is
Akihiro Honda1, Nobuhiro Tahara2, Yoshikazu Nitta1
1From the Division of Cardiovascular Medicine, Department of Medicine (A.H., N.T., Y.N., A.T., S.I., M.B., T.N., Y.S., M.E., H.A., Y.F.), Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications (S-i.Y.), and Department of Radiology (H.K., S.K., K.F., T.A.), Kurume University School of Medicine, Kurume, Japan; and Department of Cardiology, Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (J.N.).
Arteriosclerosis, Thrombosis, and Vascular Biology
|July 9, 2016
Summary
Vascular inflammation, assessed noninvasively, is linked to endothelial dysfunction in humans. This finding highlights a new diagnostic approach for atherosclerotic cardiovascular disease risk.
Area of Science:
- Cardiovascular Medicine
- Medical Imaging
- Vascular Biology
Background:
- Endothelial dysfunction is a key early event in atherosclerotic cardiovascular disease.
- Noninvasive assessment of vascular inflammation in humans is limited.
- Understanding the link between vascular inflammation and endothelial dysfunction is crucial for early diagnosis.
Purpose of the Study:
- To investigate the relationship between endothelial function and vascular inflammation in humans.
- To assess if [18F]-fluorodeoxyglucose-positron emission tomography/computed tomography can evaluate vascular inflammation.
- To determine the association between carotid artery inflammation and endothelial dysfunction.
Main Methods:
- 145 subjects underwent flow-mediated dilation (FMD) for endothelial function and [18F]-FDG-PET/CT for carotid artery inflammation.
- Vascular inflammation was quantified using target:background ratio (TBR).
- Changes in FMD (%FMD) and TBR (ΔTBR) were analyzed after antihypertensive treatment in 33 patients.
Main Results:
- Age, LDL-cholesterol, and TBR were independently associated with %FMD.
- A significant inverse correlation was found between changes in FMD and TBR after treatment (r=-0.558, P<0.001).
- ΔTBR was the sole independent associate of Δ%FMD in hypertensive patients.
Conclusions:
- Vascular inflammation in carotid arteries, evaluated by [18F]-FDG-PET/CT, is an independent correlate of decreased endothelial function (%FMD).
- This study suggests a direct association between vascular inflammation and endothelial dysfunction in humans.
- Noninvasive imaging of vascular inflammation may offer new insights into atherosclerotic cardiovascular disease pathogenesis.
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