Antibacterial Effect of Silver-Incorporated Flake-Shell Nanoparticles under Dual-Modality

Silver has been recognized as a broad-spectrum antimicrobial agent and extensively used in biomedical applications. Through a sequential one-pot synthesis strategy, we have successfully incorporated silver into flake-shell nanoparticles. Due to the simultaneous growth of networked nanostructures of silica and in situ reduction of silver ions, homogeneously distributed silver into the shell of the nanocapsule was formed. The antibacterial test indicated that the silver-incorporated silica nanocapsule exhibits effective antibacterial activity, inhibiting the bacterial growth by 75%. In addition, with the encapsulation of other antibiotic agent into the structure, an enhanced antibacterial effect under dual-modality could also be achieved.