Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma

Related Experiment Video

Updated: Mar 18, 2026

Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment
07:25

Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment

Published on: March 1, 2024

3.2K

Josep Puig1, Javier Sánchez-González2, Gerard Blasco1

  • 1Imaging Research Unit, Institut de Diagnostic per la Imatge (IDI), Girona Biomedical Research Institute (IDIBGI), Hospital Universitari Dr Josep Trueta, Girona, Spain.

Plos One
|July 9, 2016
PubMed
Abstract

Insights

Intravoxel incoherent motion (IVIM) MRI metrics, specifically perfusion fraction (f) and pseudodiffusion coefficient (D*) in contrast-enhancing regions, show promise for predicting 6-month survival in glioblastoma patients. Combining these IVIM metrics with treatment information offers high accuracy in survival prediction.

Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Intravoxel incoherent motion (IVIM) MRI is a technique for measuring brain tumor perfusion.
  • Its clinical utility in predicting glioblastoma survival requires further investigation.

Purpose of the Study:

  • To assess the effectiveness of IVIM-derived metrics in predicting survival for patients with newly diagnosed glioblastoma.
  • To identify specific IVIM parameters and their thresholds associated with 6-month survival.

Main Methods:

  • Fifteen glioblastoma patients underwent MRI with diffusion-weighted imaging (DWI) at 13 b-values.
  • Parametric maps of diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) were generated for contrast-enhancing (CER) and non-enhancing (NCER) regions.
  • Kaplan-Meier and Cox proportional hazards analyses were used to evaluate prognostic factors.

Main Results:

  • Perfusion fraction in contrast-enhancing regions (fCER) and pseudodiffusion coefficient in contrast-enhancing regions (D*CER) correlated with cerebral blood volume.
  • Optimal cutoffs for 6-month survival were identified as fCER > 9.86% and D*CER > 21.712 x10-3mm2/s.
  • Treatment was a significant prognostic factor (HR=5.484), and fCER combined with treatment predicted survival with 100% accuracy.

Conclusions:

  • IVIM-derived metrics, fCER and D*CER, are valuable biomarkers for predicting 6-month survival in newly diagnosed glioblastoma.
  • These IVIM parameters hold potential for clinical application in glioblastoma prognosis.

More Related Videos

Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning10:25

Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning

Published on: April 12, 2024

2.6K
Stereotactic Intracranial Implantation and In vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme10:52

Stereotactic Intracranial Implantation and In vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme

Published on: September 25, 2012

26.6K

Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
351
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
448