Bio-inspired metal ions regulate the structure evolution of self-assembled peptide-based nanoparticles.

Area of Science:

• Biomaterials Science
• Supramolecular Chemistry
• Nanotechnology

Background:

• Supramolecular modules offer versatile platforms for advanced applications.
• Controlled self-assembly and transformation are key for functional nanomaterials.

Purpose of the Study:

• To investigate the assembly and transformation of the BP-KLVFF-RGD (BKR) supramolecular module.
• To explore its potential for in situ imaging and therapeutic applications on living cell surfaces.

Main Methods:

• Characterization of BKR self-assembly in solution.
• In situ observation of BKR transformation on cell surfaces.
• Utilizing calcium ion coordination to induce structural changes.

Main Results:

• BKR spontaneously self-assembled into nanoparticles.
• Nanoparticles transformed into nanofibers upon calcium ion coordination.
• Demonstrated assembly and transformation on living cell surfaces.

Conclusions:

• The BP-KLVFF-RGD module exhibits controllable self-assembly and in situ transformation.
• This provides a novel strategy for developing functional nanostructures for biomedical applications.
• Potential for targeted imaging and treatment delivery.