Related Experiment Video
Updated: Mar 18, 2026
A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Comparisons of GFR estimation using the CKD Epidemiology Collaboration (CKD-EPI) equation and other creatinine-based
Patcharaporn Sudchada1,2, Spencer Laehn3
1Pharmaceutical Care Research Unit, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Ta-Poe, Meaung, Phitsanulok, 65000, Thailand. psudchada@gmail.com.
Purpose:
The aim of the study was to summarize the evidence of the validation of CKD-EPI equation and alternative creatinine-based equations in Asian population.
Methods:
Relevant validation studies of CKD-EPI and other creatinine-based equations were identified by a systematic literature searching of PubMed conducted from January 2009 through August 2014. Searching terms included "CKD EPI", "Kidney function test [MeSH] and validation", and "Glomerular filtration rate [MeSH] and validation" without language or design of study restrictions. The quality of each study was assessed using Quality Assessment of diagnostic Accuracy studies-2 tool.
Results:
Of 1064 studies identified, 10 studies were included in the present systematically review. The CKD-EPI equation has been validated in several Asian population including Thai, Japanese, Chinese, Taiwanese, Pakistani as well as Arabic. CKD-EPI equation met the clinically significant 75 % P30 value in several populations, although corrections of some factors may increase the accuracy of the equation. However, some populations may need to find more accurate equations or methods to estimate GFR for the patients.
Conclusions:
CKD-EPI is a good equation to start with for estimation of patients' renal function but for certain disease states and racial populations, the CKD-EPI should be validated before applying. More research is needed in order to develop validated eGFR equations for specific populations and to improve upon the accuracies of currently acceptable equations to better guide therapy and improve patient outcomes.
Related Concept Videos
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
01:25Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
01:25Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
01:17Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
01:08Renal Drug Clearance: Comparison Between Renal Excretion Methods
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...