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Related Concept Videos

Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...

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Related Experiment Video

Updated: Jul 12, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
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[Optical coherence tomography angiography (OCT‑A) in rats].

J H Meyer1, P P Fang1, T U Krohne1

  • 1Universitäts-Augenklinik Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Deutschland.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|July 9, 2016
PubMed
Summary

Optical coherence tomography angiography (OCT-A) enables non-invasive, 3D visualization of retinal and chorioidal vasculature in rats. This advanced imaging may replace traditional fluorescein angiography for studying angiogenic processes in animal models.

Keywords:
Fluorescein angiographyIn vivo imagingOCT-angiographyOCT‑ARat

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Animal Models

Background:

  • Optical coherence tomography angiography (OCT-A) offers non-invasive, 3D visualization of retinal and chorioidal vasculature.
  • Evaluating novel imaging modalities in animal models is crucial for advancing research.

Purpose of the Study:

  • To evaluate the utility of OCT-A for imaging retinal and chorioidal vascular structures in rats.
  • To compare OCT-A with conventional fluorescein angiography (FA) in a rodent model.

Main Methods:

  • In vivo imaging was performed in Dark Agouti rats using OCT-A and confocal scanning laser ophthalmoscopy (cSLO).
  • OCT-A en-face images were compared to cSLO FA images.
  • Histological examination was used for correlation.

Main Results:

  • OCT-A, with minor modifications, is applicable to rodents, providing high-resolution, depth-selective images of retinal and choroidal vascular networks.
  • OCT-A demonstrated superior resolution and 3D localization compared to FA, especially in deeper layers.
  • A limitation is the relatively small field of view with OCT-A.

Conclusions:

  • OCT-A allows for 3D in vivo detection of vascular changes in rodents without dye injection.
  • OCT-A shows potential to replace FA for specific research questions in animal models.
  • This technique will be valuable for studying retinal and chorioidal angiogenesis in physiological and pharmacological contexts.