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Relationship between Regional Fat Distribution and Hypertrophic Cardiomyopathy Phenotype

Valeria Guglielmi1, Luciano Maresca2, Chiara Lanzillo3

  • 1Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.

Plos One
|July 9, 2016
PubMed

Insights

Truncal fat, but not other regional fat depots, is linked to increased interventricular septum thickness in hypertrophic cardiomyopathy (HCM) patients. This suggests central adiposity may influence HCM phenotype, warranting further research.

Area of Science:

  • Cardiology
  • Genetics
  • Metabolic Diseases

Background:

  • Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, presenting with varied phenotypes.
  • Body mass index (BMI) correlates with left ventricular (LV) mass and heart failure symptoms in HCM.
  • Regional fat distribution's role in HCM hypertrophy severity and pattern remains unclear.

Purpose of the Study:

  • To investigate the relationship between regional fat distribution (trunk, appendicular, epicardial) and hypertrophy severity in HCM.
  • To explore potential links between specific fat depots and the hypertrophic pattern in HCM patients.

Main Methods:

  • 32 HCM patients (22M/10F, 57.2±12.6 years) with predominant interventricular septum (IVS) hypertrophy underwent cardiovascular magnetic resonance.
  • Regional fat distribution was quantified using dual-energy X-ray absorptiometry.
  • Statistical analyses adjusted for age and gender to assess associations.

Main Results:

  • Maximum IVS thickness correlated significantly with truncal fat (Tr-FAT), but not appendicular or epicardial fat.
  • Epicardial fat showed an independent association with NT-proBNP levels.
  • Late Gadolinium Enhancement (LGE)-positive subjects had greater IVS thickness, LV mass index, and NT-proBNP levels, without significant fat associations.

Conclusions:

  • Truncal fat, not appendicular or epicardial fat, appears related to increased IVS thickness in this HCM cohort.
  • Central adiposity may influence the hypertrophic phenotype in HCM.
  • Further prospective studies are required to establish a causal link between central adiposity and HCM phenotype.
Abstract

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