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Updated: Sep 27, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

Effects of N-substitution on the activation mechanisms of 4-hydroxycyclophosphamide analogues

C H Kwon1, R F Borch

  • 1Department of Pharmacology, University of Rochester, New York 14642.

Journal of Medicinal Chemistry
|July 1, 1989
PubMed

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Historical perspective
In 1896, the German chemist Paul Walden discovered that he could interconvert pure enantiomeric (+) and (-) malic acids through a series of reactions. This conversion suggested the involvement of optical inversion during the substitution reaction. Further, in 1930, Sir Christopher Ingold described for the first time two different forms of nucleophilic substitution reactions, which are known as SN1 (nucleophilic substitution unimolecular) and SN2 (nucleophilic substitution...
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