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Predicting bifurcation angle effect on blood flow in the microvasculature
Jiho Yang1, Y Eugene Pak1, Tae-Rin Lee1
1Advanced Institutes of Convergence Technology, Seoul National University, Suwon 443-270, Republic of Korea.
Microvascular Research
|July 9, 2016
Summary
Vessel bifurcation significantly impacts blood flow resistance in microvasculature, independent of angle. This finding offers new insights for predicting blood viscosity and improving hemodynamic models in microvascular research.
Area of Science:
- Physiology
- Biophysics
- Fluid Dynamics
Background:
- Blood viscosity is crucial for understanding hemodynamics.
- Previous models often overlook hemodynamic changes in heterogeneous microvascular networks.
- Accurate prediction of non-Newtonian blood flow properties is challenging.
Purpose of the Study:
- To quantitatively predict the effect of bifurcation on hemodynamics in microvasculature.
- To develop a new mathematical model incorporating bifurcation effects.
- To investigate the influence of bifurcation angle on flow resistance.
Main Methods:
- Combined a novel mathematical model with 3D flow simulations.
- Calculated flow resistance in single bifurcation microvessels.
- Simulated physiological flow conditions with varying bifurcation angles.
Main Results:
- Flow resistance at bifurcation remained constant (~0.44) for vessels <60μm, irrespective of bifurcation angle.
- The new model predicted lower flow velocity and similar pressure compared to models without bifurcation.
- Simulations incorporating bifurcation effects showed improved agreement with in vivo measurements.
Conclusions:
- Vessel bifurcation, regardless of angle, substantially influences blood viscosity in microvasculature.
- This phenomenon provides a new perspective for microvascular blood flow properties.
- The findings can aid in developing advanced predictive tools for microvascular research.
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