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Updated: Mar 18, 2026

Model of Ischemia and Reperfusion Injury in Rabbits
Published on: November 3, 2023
Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury
1Second Hospital of HeBei Medical University, Shijiazhuang, HeBei 050000, PR China.
Abstract:
We describe several novel curcumin analogues that possess both anti-inflammatory antioxidant properties and thrombolytic activities. The therapeutic efficacy of these curcumin analogues was verified in a mouse ear edema model, a rat arterial thrombosis assay, a free radical scavenging assay performed in PC12 cells, and in both in vitro and in vivo ischemia/reperfusion models. Our findings suggest that their protective effects partially reside in maintenance of optimal mitochondrial function.
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