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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Multi-target siRNA: Therapeutic Strategy for Hepatocellular Carcinoma
Tiejun Li1, Yuwen Xue2, Guilan Wang2
11. Department of Pathological Anatomy, Nantong University, Nantong, China;; 2. Small RNA Technology and Application Institute, Nantong University, Nantong, China;; 3. Biomics Biotechnologies Co., Ltd., Nantong, China.
Abstract:
Multiple targets RNAi strategy is a preferred way to treat multigenic diseases, especially cancers. In the study, multi-target siRNAs were designed to inhibit NET-1, EMS1 and VEGF genes in hepatocellular carcinoma (HCC) cells. And multi-target siRNAs showed better silencing effects on NET-1, EMS1 and VEGF, compared with single target siRNA. Moreover, multi-target siRNA showed greater suppression effects on proliferation, migration, invasion, angiogenesis and induced apoptosis in HCC cells. The results suggested that multi-target siRNA might be a preferred strategy for cancer therapy and NET-1, EMS1 and VEGF could be effective targets for HCC treatments.
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