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Epinephrine and left atrial and left ventricular diastolic function decrease in normal subjects.
Abdel J Fuenmayor1, Moisés I Solórzano1, Luisangelly Gómez1
1Cardiovascular Research Institute "Abdel M. Fuenmayor P", University Hospital of The Andes, Mérida, Venezuela.
International Journal of Cardiology
|July 9, 2016
Summary
Epinephrine infusion in young adults without heart disease is safe. It caused minor decreases in left atrial and left ventricular diastolic function, affecting heart performance.
Area of Science:
- Cardiology
- Pharmacology
- Physiology
Background:
- Assessing the impact of epinephrine on cardiac function in healthy individuals.
- Focus on left atrial and left ventricular diastolic function.
Purpose of the Study:
- To evaluate the effects of epinephrine on diastolic function in subjects without structural heart disease.
- To determine the safety and functional impact of epinephrine administration.
Main Methods:
- Echocardiography used to assess left atrial and ventricular function.
- Intravenous epinephrine infusion administered at 50-100 ng/kg/min.
- Evaluations conducted before and during epinephrine infusion in 27 participants.
Main Results:
- Epinephrine infusion was safe with no observed complications.
- Significant increases in heart rate and systolic blood pressure noted.
- Left atrial function showed decreased expansion index and ejection fraction; left ventricular diastolic function parameters (E/A, e') decreased, and isovolumetric relaxation time increased.
Conclusions:
- Epinephrine infusion is safe in young adults without structural heart disease.
- A small but significant decrease in left atrial and left ventricular diastolic function was observed.
- Epinephrine administration can alter diastolic function parameters even in healthy individuals.
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