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A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
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Maternal obesity and prenatal programming.

Summer Elshenawy1, Rebecca Simmons2

  • 1Children's Hospital of Philadelphia, 3516 Civic Center Boulevard, Philadelphia, PA 19104, USA.

Molecular and Cellular Endocrinology
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Summary
This summary is machine-generated.

Maternal obesity during pregnancy can epigenetically program offspring for long-term health issues, impacting future generations. Understanding these effects is crucial for reducing obesity rates globally.

Keywords:
Developmental programmingEpigeneticsFetal origins of adult diseaseMaternal obesityObesity in pregnancy

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Area of Science:

  • Public Health
  • Epigenetics
  • Developmental Biology

Background:

  • Obesity is a growing global health crisis with complex genetic and environmental origins.
  • Maternal obesity poses risks beyond childbirth, influencing fetal development and long-term health.
  • Epigenetics offers a framework to understand how environmental factors like maternal obesity affect gene expression.

Purpose of the Study:

  • To explore the link between maternal obesity and epigenetic modifications in offspring.
  • To highlight the long-term and transgenerational implications of fetal programming in obesity.
  • To emphasize the need for research into interventions targeting obesity's developmental and inherited aspects.

Main Methods:

  • Review of clinical and epidemiological evidence on maternal obesity and offspring health.
  • Analysis of emerging research on molecular and epigenetic findings in offspring of obese mothers.
  • Synthesis of data on fetal programming during pregnancy.

Main Results:

  • Maternal obesity is associated with epigenetic changes that can influence offspring's susceptibility to obesity.
  • These epigenetic effects can lead to detrimental health outcomes in offspring and potentially future generations.
  • A clear link exists between maternal obesity, fetal programming, and offspring's clinical/molecular profiles.

Conclusions:

  • Epigenetic alterations resulting from maternal obesity play a critical role in offspring's long-term health.
  • Interventions aimed at reducing the transgenerational inheritance of obesity are essential.
  • Further research is vital to understand and mitigate the impact of maternal obesity on developmental programming.