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Updated: Mar 18, 2026
High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
Published on: November 15, 2013
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Laurent Bourguignon1, Sylvain Goutelle1, Cécile Gérard2
1Université de Lyon 1, ÉcoleDoctorale E2M2 «Évolution, Écosystèmes, Microbiologie, Modélisation», UMR 5558, «Biométrie et Biologie Évolutive », Villeurbanne, France; Hospices Civils de Lyon, Hôpital Antoine Charial, Service Pharmacie, Francheville, France; ADCAPT, Hôpital Antoine Charial, Service Pharmacie, Francheville, France.
Abstract:
The use of amikacin is difficult because of its toxicity and its pharmacokinetic variability. This variability is almost ignored in adult standard dosage regimens since only the weight is used in the dose calculation. Our objective is to test if the pharmacokinetic of amikacin can be regarded as homogenous, and if the method for calculating the dose according to patients' weight is appropriate. From a cohort of 580 patients, five groups of patients were created by statistical data partitioning. A population pharmacokinetic analysis was performed in each group. The adult population is not homogeneous in term of pharmacokinetics. The doses required to achieve a maximum concentration of 60mg/L are strongly different (585 to 1507mg) between groups. The exclusive use of the weight to calculate the dose of amikacine appears inappropriate for 80% of the patients, showing the limits of the formulae for calculating doses of aminoglycosides.
