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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

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[Not Available].

Elodie Blanchard1, Manuel Tunon de Lara1

  • 1Service des Maladies Respiratoires, Hôpital Haut Lévêque, Pessac, France.

Therapie
|July 10, 2016
PubMed
Summary
This summary is machine-generated.

Pholcodine effectively treats cough, showing superior efficacy and duration compared to codeine with a safer profile. Ongoing research addresses potential cross-sensitization with neuromuscular blocking agents.

Keywords:
coughcurareefficacitéefficacyneuromuscular blocking agentspholcodinetolerancetolérancetoux

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Area of Science:

  • Pharmacology
  • Clinical Therapeutics
  • Drug Safety

Context:

  • Pholcodine, an opioid antitussive, has been used since 1950 for non-productive cough.
  • Its efficacy and safety profile have been compared to codeine in preclinical and clinical studies.

Purpose:

  • To evaluate the antitussive efficacy and safety of pholcodine.
  • To address concerns regarding potential cross-sensitization with neuromuscular blocking agents.

Summary:

  • Pholcodine demonstrates superior efficacy and longer duration of action for cough suppression than codeine.
  • It possesses an equivalent or safer toxicity profile and carries no risk of addiction.
  • The European Medicines Agency (EMA) confirmed a favorable risk-benefit ratio, pending further investigation into cross-sensitization.

Impact:

  • Pholcodine represents a valuable therapeutic option for cough management.
  • Further research is crucial to fully elucidate its safety profile concerning neuromuscular blocking agents.