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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
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Published on: November 15, 2013

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[Not Available].

Danièle Bentué-Ferrer1, Olivier Tribut1, Marie-Clémence Verdier1

  • 1Laboratoire de Pharmacologie Biologique, CHU Pontchaillou, Rennes, France.

Therapie
|July 10, 2016
PubMed
Summary

Tiagabine is an anticonvulsant used for epilepsy and anxiety. Limited studies show variable serum levels, necessitating dose adjustments for liver impairment and therapeutic drug monitoring.

Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Neuroscience

Context:

  • Tiagabine, a second-generation anticonvulsant, has been available in France since 1997.
  • It is also used off-label for anxiety treatment.
  • Significant inter-individual variability in serum concentrations is noted, with few studies correlating exposure with efficacy or toxicity.

Purpose:

  • To evaluate the evidence supporting Therapeutic Drug Monitoring (TDM) for tiagabine.
  • To highlight the need for dose adaptation in cases of hepatic insufficiency.
  • To establish therapeutic serum concentration ranges for tiagabine.

Summary:

  • Tiagabine exhibits considerable variability in serum concentrations among patients.
  • Therapeutic doses typically result in serum levels between 20-100 μg/L (50-250 nmol/L).
Keywords:
pharmacologiquesuivi thérapeutiquetherapeutic drug monitoringtiagabine

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  • Hepatic insufficiency mandates careful dose adjustment.

    • Impact:

    • Understanding tiagabine pharmacokinetics is crucial for optimizing treatment outcomes.
    • Further research is needed to fully establish the role and benefits of TDM for tiagabine.
    • This information aids clinicians in managing tiagabine therapy, particularly in patients with liver conditions.