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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Eric Dailly¹, Régis Bouquié¹, Danièle Bentué-Ferrer²

¹Service de Pharmacologie Clinique, CHU de Nantes, Nantes, France; EA 4275 Biostatistique, Recherche Clinique et Mesures Subjectives en Santé, Faculté de Médecine - Pharmacie, Université de Nantes, France.

|July 10, 2016

Summary

This summary is machine-generated.

This review found that while factors like age and kidney function affect levetiracetam levels, there is no clear link between levetiracetam concentration and its effectiveness or side effects. Individualized monitoring may be beneficial in certain cases, especially before pregnancy.

Keywords:

levetiracetam lévétiracétam suivi thérapeutique pharmacologique therapeutic drug monitoring

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Area of Science:

Pharmacology
Clinical Pharmacy
Evidence-Based Medicine

Context:

Levetiracetam is a widely used anticonvulsant for various seizure types.
Current therapeutic drug monitoring (TDM) guidelines do not routinely recommend levetiracetam monitoring.
Understanding factors influencing levetiracetam pharmacokinetics is crucial for optimizing patient outcomes.

Purpose:

To review the literature on levetiracetam pharmacokinetics and its relationship with efficacy and toxicity.
To identify patient-specific factors affecting levetiracetam concentrations.
To evaluate the potential utility of therapeutic drug monitoring for levetiracetam.

Summary:

Literature review using evidence-based medicine identified age, renal failure, pregnancy, and drug interactions as key factors influencing levetiracetam pharmacokinetics.
No significant correlation was found between levetiracetam plasma concentration and its efficacy or toxicity.
Typical therapeutic concentrations range from 6 to 18 mg/L.

Impact:

Individualized therapeutic concentration determination may be beneficial, particularly for patients planning pregnancy.
Therapeutic drug monitoring for levetiracetam, though not currently standard, could be valuable in specific clinical scenarios.
This review informs clinical practice regarding levetiracetam management and potential monitoring strategies.