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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Anne Hulin¹, Bernard Royer², Etienne Chatelut³

¹CHU Henri Mondor, AP-HP, Université Paris XII, Créteil, France.

|July 10, 2016

Summary

This summary is machine-generated.

Cisplatin monitoring may help reduce kidney damage by measuring maximal concentration. Further research is needed to establish its link to efficacy and guide dosing in special populations.

Keywords:

cisplatin cisplatine elderly level of evidence niveau de preuve suivi thérapeutique pharmacologique therapeutic drug monitoring

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Last Updated: Mar 18, 2026

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Area of Science:

Pharmacology
Oncology
Toxicology

Context:

Cisplatin is a vital chemotherapy drug with significant nephrotoxicity.
Protein binding and concentration impact cisplatin's effects.
Current monitoring focuses on toxicity, not efficacy.

Purpose:

To evaluate the role of cisplatin monitoring in optimizing treatment.
To explore the relationship between cisplatin exposure, efficacy, and toxicity.
To identify needs for therapeutic drug monitoring in diverse patient groups.

Summary:

Studies link cisplatin concentration to nephrotoxicity but not efficacy.
Population modeling shows low variability but highlights special populations needing consideration.
Pharmacogenetic impact on monitoring requires investigation.

Impact:

Therapeutic monitoring of cisplatin, focusing on maximal concentration, may be beneficial.
Adjusted modeling and prospective studies are essential for validating monitoring strategies.
Optimizing cisplatin dosing can improve patient outcomes and reduce adverse events.