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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Anne Hulin¹, Etienne Chatelut², Bernard Royer³

¹CHU Henri Mondor, AP-HP, Université Paris XII, Créteil, France.

|July 10, 2016

Summary

This summary is machine-generated.

Therapeutic drug monitoring of carboplatin is recommended to manage toxicity. Measuring the area under the concentration-time curve (AUC) of ultrafiltrable carboplatin concentrations aids in optimizing dosing for cancer patients.

Keywords:

carboplatin carboplatine suivi thérapeutique pharmacologique therapeutic drug Monitoring

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Last Updated: Mar 18, 2026

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Area of Science:

Pharmacology
Oncology
Clinical Chemistry

Context:

Carboplatin is a key chemotherapy agent for various cancers in adults and children.
High protein binding of carboplatin influences its pharmacokinetics and toxicity.
Hematotoxicity is a significant side effect requiring careful management.

Purpose:

To explore the relationship between carboplatin exposure and patient outcomes.
To evaluate the utility of population pharmacokinetic modeling for carboplatin dosing.
To identify specific patient populations needing tailored carboplatin dosing strategies.

Summary:

Studies link carboplatin exposure (AUC of ultrafiltrable concentrations) to myelotoxicity.
Population modeling reveals low variability in carboplatin exposure parameters.
Therapeutic drug monitoring of ultrafiltrable carboplatin AUC is recommended for dose adjustment.

Impact:

Establishes the importance of therapeutic drug monitoring for carboplatin efficacy and safety.
Highlights the need for individualized dosing in specific populations like children and renally impaired patients.
Provides a framework for optimizing carboplatin treatment regimens through adjusted modeling.