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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Chantal Le Guellec¹, Hélène Blasco¹, Isabelle Benz¹

¹Université François Rabelais de Tours ; CHRU de Tours, France.

|July 10, 2016

Summary

This summary is machine-generated.

Monitoring serum methotrexate (MTX) concentrations after high-dose infusions helps reduce toxicity by guiding leucovorin dose adjustments. This practice, though lacking prospective trials, has historically decreased MTX-related adverse events.

Keywords:

high-dose methotrexate level of evidence méthotrexate haute dose niveau de preuve

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Last Updated: Mar 18, 2026

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Area of Science:

Pharmacology
Oncology
Clinical Pharmacy

Context:

High-dose methotrexate (HDMTX) infusions are used in treating various cancers.
Monitoring serum MTX concentrations is crucial for managing toxicity.
Decreased MTX clearance necessitates careful dose adjustments.

Purpose:

To summarize the importance of therapeutic drug monitoring (TDM) for methotrexate.
To highlight the role of serum MTX concentration monitoring in guiding leucovorin rescue.
To discuss the historical evidence supporting MTX TDM in reducing toxicity.

Summary:

Therapeutic monitoring of methotrexate involves serial serum concentration measurements to ensure levels fall below a safe threshold.
This practice is supported by observational data linking drug exposure to toxicity.
Historical data indicates a significant reduction in MTX toxicity events correlating with TDM implementation.

Impact:

Reduces the incidence of methotrexate-related toxicity in patients.
Guides timely leucovorin dose adjustments for optimized patient outcomes.
Facilitates early identification of patients requiring immediate intervention, such as carboxypeptidase treatment.