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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Pauline Gerritsen-van Schieveen¹, Bernard Royer²,

¹CHU Besançon, Laboratoire de Pharmacologie Clinique, Hôpital Jean Minjoz, Besançon, France.

|July 10, 2016

Summary

This summary is machine-generated.

Therapeutic drug monitoring for paclitaxel may be beneficial. Maintaining plasma concentrations above 0.05 μmol/L is a key target, but requires validation for weekly administration schedules.

Keywords:

level of evidence niveau de preuve paclitaxel

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Area of Science:

Pharmacology
Oncology
Clinical Pharmacy

Context:

Paclitaxel is a vital chemotherapy agent.
Its use necessitates understanding pharmacokinetic properties.
Therapeutic drug monitoring (TDM) is being considered for paclitaxel.

Purpose:

To evaluate the utility of therapeutic drug monitoring for paclitaxel.
To assess the significance of specific pharmacokinetic parameters, such as time above a target concentration.
To determine if TDM is potentially useful for optimizing paclitaxel therapy.

Summary:

Paclitaxel's pharmacokinetic profile suggests a need for therapeutic drug monitoring.
The most effective parameter appears to be maintaining plasma concentrations above 0.05 μmol/L.
This target requires further validation, especially with novel weekly administration schedules.

Impact:

This study informs the potential clinical utility of therapeutic drug monitoring for paclitaxel.
Findings may guide the development of optimized dosing strategies.
It highlights the need for evidence-based TDM protocols in cancer chemotherapy.