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Related Experiment Video

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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

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[Not Available].

Danièle Bentué-Ferrer¹, Olivier Tribut¹, Marie-Clémence Verdier¹

¹Laboratoire de Pharmacologie Biologique, CHU Pontchaillou, Rennes, France.

Therapie

|July 10, 2016

Summary

Valproic acid, an anticonvulsant, is used for epilepsy and bipolar disorders. Despite its common use, Therapeutic Drug Monitoring (TDM) for valproate has shown limited benefit, though drug interactions are a concern.

Area of Science:

Pharmacology
Neuroscience

Context:

Valproic acid, available since 1967, is a broad-spectrum anticonvulsant for epilepsy and other nervous system disorders.
Divalproate sodium is indicated for bipolar disorder treatment.
Valproic acid is available in various pharmaceutical forms, with the circulating active molecule being the valproate ion.

Purpose:

To review the clinical use and therapeutic drug monitoring (TDM) of valproic acid.
To discuss the concentration-effect relationship and variability in valproate plasma concentrations.
To highlight potential drug interactions affecting valproate levels.

Summary:

Valproic acid exhibits significant inter- and intra-individual variability in plasma concentrations.
Metabolization is the primary route of valproate elimination, with a half-life of 11-20 hours.

Keywords:

suivi thérapeutique pharmacologique therapeutic drug monitoring valproate

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Despite a known concentration-effect relationship, two trials questioned the utility of TDM, although it remains current practice due to drug interactions.

Impact:

Valproate TDM is recommended, with a therapeutic range of 50-100 mg/L.
Understanding valproate pharmacokinetics and interactions is crucial for effective patient management.
Further research may clarify the precise role of TDM in optimizing valproate therapy.