Redox signaling: An evolution from free radicals to aging
1Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, United States.
Free Radical Biology & Medicine
|July 10, 2016
Summary
Redox biology has evolved to understand how oxidants are crucial for normal and abnormal cell signaling. This field, redox signaling, is vital for homeostasis and disease, impacting areas like aging.
Area of Science:
- * Redox biology and signal transduction.
- * Molecular mechanisms of cell signaling.
Background:
- * The historical trajectory of redox biology from oxidant pathology to signaling roles.
- * Key discoveries including superoxide dismutase and the role of hydrogen peroxide (H2O2).
Purpose of the Study:
- * To review the historical development of redox biology and redox signaling.
- * To provide insights into the physiological and pathological roles of redox signaling.
Main Methods:
- * Historical review based on personal experience in the field.
- * Synthesis of key findings in redox biology and signaling.
Main Results:
- * Evolution from focusing on oxidant damage to understanding signaling pathways.
- * Recognition of hydrogen peroxide (H2O2) and electrophiles in physiological signaling.
- * Establishment of redox signaling as a critical overlap between signal transduction and redox biology.
Conclusions:
- * Redox signaling is essential for maintaining physiological homeostasis.
- * Dysregulation of redox signaling is implicated in aging and various diseases.
- * Understanding redox signaling mechanisms is crucial for therapeutic interventions.
Keywords:
AP-1AgingAir pollutionAntioxidantGlutathioneHomeostasisHydrogen peroxideNADPH oxidaseNrf2Oxidative stressRedox signalingSuperoxideThiolateMore Related Videos
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