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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Lukshe Kanagaratnam¹, Malak Abou Taam¹, Marie Heng¹

¹Centre Régional de Pharmacovigilance et de Pharmacoépidémiologie de Champagne-Ardenne, Centre Hospitalier Universitaire de Reims, Reims, France.

|July 10, 2016

Summary

This summary is machine-generated.

Over a quarter of serious adverse drug reactions (ADRs) in elderly patients were preventable. Key causes included off-label drug use and non-compliance, highlighting areas for improved medication safety in older adults.

Keywords:

adverse drug reactions effet indésirable médicamenteux elderly pharmacovigilance preventability sujet âgé évitabilité

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Area of Science:

Geriatric pharmacovigilance
Drug safety research
Clinical pharmacology

Context:

Focuses on elderly individuals (aged over 65 years).
Examines serious adverse drug reactions (ADRs).
Conducted at a Regional Pharmacovigilance Center in France.

Purpose:

To describe serious ADRs in the elderly population.
To assess the preventability of these serious ADRs.
To identify factors contributing to preventable ADRs.

Summary:

A retrospective study included 100 elderly subjects with serious ADRs.
Twenty-seven percent of serious ADRs were found to be preventable.
Bleeding events were the most common serious ADR (36%), with antithrombotic agents being the most frequently implicated drugs (31.4%).
Off-label use (20%) and non-compliance (5%) were primary causes of preventable serious ADRs.

Impact:

Highlights the significant proportion of preventable serious ADRs in the elderly.
Underscores the importance of addressing off-label prescribing and patient compliance.
Provides data to inform strategies for enhancing medication safety in geriatric patients.