Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Availability Heuristic01:08

The Availability Heuristic

7.2K
A heuristic is a general problem-solving framework (Tversky & Kahneman, 1974). You can think of these as mental shortcuts that are used to solve problems. Different types of heuristics are used in different types of situations, and the impulse to use a heuristic occurs when one of five conditions is met (Pratkanis, 1989):
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mediastinal Lymphadenopathy: Associations Between Computed Tomography Characteristics and Final Etiological Diagnoses in 200 Patients.

Cureus·2026
Same author

Massive Hemoptysis Revealing Rasmussen's Aneurysm in Active Pulmonary Tuberculosis: A Report of a Fatal Case.

Cureus·2026
Same author

Delayed Hypersensitivity Reaction to Insulin: A Case Report.

Cureus·2026
Same author

Helicobacter pylori eradication rate following first line non-bismuth quadruple therapy regimen in Tunisian patients: the HPERAD study.

BMC infectious diseases·2025
Same author

Pulmonary Inflammatory Myofibroblastic Tumor in a Patient Treated for Pemphigus Vulgaris: A Case Report.

Cureus·2025
Same author

Common Variable Immunodeficiency Revealed by Bronchiectasis: A Case Report.

Cureus·2025

Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

48.7K

[Not Available].

Salma Melaouhia1, Monia Fékih2, Henda Ferchichi1

  • 1Service de Pharmacologie clinique, Centre national de Pharmacovigilance, Tunis, Tunisie.

Therapie
|July 10, 2016
PubMed
Summary

Azathioprine metabolite levels correlate with myelotoxicity in inflammatory bowel disease patients. This finding aids in predicting and managing adverse effects during treatment.

Keywords:
6- methyl mercaptopurine6-méthyl mercaptopurine6-thioguanine nucleotide6-thioguaninenucléotideazathioprineinflammatory bowel diseasemaladie inflammatoire chronique de l’intestin

More Related Videos

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
14:02

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

25.1K
A Submerged Filter Paper Sandwich for Long-term Ex Ovo Time-lapse Imaging of Early Chick Embryos
07:29

A Submerged Filter Paper Sandwich for Long-term Ex Ovo Time-lapse Imaging of Early Chick Embryos

Published on: December 28, 2016

22.8K

Related Experiment Videos

Last Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

48.7K
Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
14:02

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

25.1K
A Submerged Filter Paper Sandwich for Long-term Ex Ovo Time-lapse Imaging of Early Chick Embryos
07:29

A Submerged Filter Paper Sandwich for Long-term Ex Ovo Time-lapse Imaging of Early Chick Embryos

Published on: December 28, 2016

22.8K

Area of Science:

  • Pharmacogenomics
  • Gastroenterology
  • Immunosuppression

Context:

  • Azathioprine is a common immunosuppressive drug for inflammatory bowel disease (IBD).
  • Monitoring azathioprine metabolite levels is crucial for optimizing treatment.
  • Understanding the relationship between metabolites and clinical outcomes is essential for patient care.

Purpose:

  • To investigate the association between azathioprine metabolites (6-thioguanine nucleotides and 6-methylmercaptopurines) and clinical efficacy.
  • To determine the correlation between these metabolites and adverse effects, specifically myelotoxicity, in IBD patients.

Summary:

  • This study analyzed 43 Crohn's disease and 7 ulcerative colitis patients treated with azathioprine for over a year.
  • Patients received azathioprine for steroid dependency, post-operative recurrence prevention, or remission maintenance.
  • A clinical response was observed in 34 patients, with metabolite levels linked to myelotoxicity.

Impact:

  • Confirms a relationship between azathioprine metabolite levels and myelotoxicity.
  • Provides insights for personalized azathioprine dosing to minimize adverse effects.
  • Supports the use of metabolite monitoring for safer and more effective IBD management.