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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Patrice Muret¹, Sarah Piedoux¹, Caroline Solas²

¹UMR 645 - IFR 133, Laboratoire de Pharmacologie Clinique et Toxicologie, CHU Besançon, France.

|July 10, 2016

Summary

This summary is machine-generated.

Therapeutic drug monitoring of nevirapine is recommended for HIV patients. Maintaining nevirapine plasma trough concentrations above 4000 ng/mL optimizes viral load suppression and prevents treatment failure.

Keywords:

level of evidence nevirapine niveau de preuve névirapine suivi thérapeutique pharmacologique therapeutic drug monitoring

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Area of Science:

Pharmacology
Infectious Diseases
Hepatology

Context:

Nevirapine, a non-nucleoside reverse transcriptase inhibitor, exhibits significant inter-individual pharmacokinetic variability due to hepatic metabolism.
Understanding nevirapine exposure is crucial for optimizing treatment outcomes in HIV-infected patients.

Purpose:

To evaluate the relevance of therapeutic drug monitoring (TDM) for nevirapine based on existing literature.
To determine optimal nevirapine plasma trough concentrations (Ctrough) for efficacy and safety.

Summary:

Nevirapine TDM is recommended, with Ctrough >4000 ng/mL associated with undetectable HIV viral load.
Lower Ctrough (<3000 ng/mL) correlates with virologic failure.
Higher Ctrough is linked to hepatotoxicity, particularly in HCV coinfected patients.

Impact:

Nevirapine TDM can optimize virologic response in HIV patients.
TDM may help mitigate nevirapine-associated hepatotoxicity, especially in coinfected individuals.
The evidence supports nevirapine TDM as a recommended strategy.