Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Availability Heuristic

The Availability Heuristic

A heuristic is a general problem-solving framework (Tversky & Kahneman, 1974). You can think of these as mental shortcuts that are used to solve problems. Different types of heuristics are used in different types of situations, and the impulse to use a heuristic occurs when one of five conditions is met (Pratkanis, 1989):

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Favipiravir tissue distribution and inhibitory quotients in preclinical models: towards a pipeline for evidence-based antiviral repurposing.

The Journal of antimicrobial chemotherapy·2026

Same authorSame journal

Multiple HIV virological failures related to bictegravir-valproic acid interaction evidenced by therapeutic drug monitoring: A retrospective study.

Therapie·2026

Same author

External Evaluation of Population Pharmacokinetic Models of Cabotegravir, During Its Oral and Intramuscular Administration in HIV-Infected Patients.

CPT: pharmacometrics & systems pharmacology·2026

Same author

Preclinical efficacy of a favipiravir and nitazoxanide combination against Rift Valley Fever Virus.

Antiviral research·2026

Same author

How Can Pharmacology Help Us Overcome the Challenges of Drug Repositioning as Antivirals to Treat Emerging Pathogens? The Example of Covid-19.

Clinical and translational science·2026

Same author

Comment on: Retrospective analysis of pharmacological therapeutic monitoring of caspofungin in patients undergoing continuous renal replacement therapy using polyacrylonitrile membranes.

The Journal of antimicrobial chemotherapy·2026

Same journal

Pharmacology of pruritus (pathophysiology, therapeutic targets).

Therapie·2026

Same journal

Barriers to prescribing methylphenidate for adults with ADHD: A qualitative study.

Therapie·2026

Same journal

[Self-medication and its factors amongst Navymen aboard surface ships of the French Navy at sea: A descriptive study].

Therapie·2026

Same journal

Subacute cutaneous lupus erythematosus induced by ticagrelor: Recurrence after rechallenge.

Therapie·2026

Same journal

Indication-related misuse of oral fluoroquinolones in adults by general practitioners in France.

Therapie·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Patrice Muret¹, Caroline Solas²,

¹UMR 645, IFR 133, Laboratoire de Pharmacologie Clinique et Toxicologie, CHU Minjoz, Besançon, France.

|July 10, 2016

Summary

This summary is machine-generated.

Therapeutic drug monitoring of saquinavir is recommended for HIV patients. Maintaining saquinavir plasma trough concentrations above 100 ng/mL is linked to achieving undetectable HIV viral load.

Keywords:

level of evidence niveau de preuve saquinavir suivi thérapeutique pharmacologique therapeutic drug monitoring

More Related Videos

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

A Submerged Filter Paper Sandwich for Long-term Ex Ovo Time-lapse Imaging of Early Chick Embryos

A Submerged Filter Paper Sandwich for Long-term Ex Ovo Time-lapse Imaging of Early Chick Embryos

Published on: December 28, 2016

Related Experiment Videos

Last Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

A Submerged Filter Paper Sandwich for Long-term Ex Ovo Time-lapse Imaging of Early Chick Embryos

A Submerged Filter Paper Sandwich for Long-term Ex Ovo Time-lapse Imaging of Early Chick Embryos

Published on: December 28, 2016

Area of Science:

Pharmacology
Infectious Diseases
Clinical Pharmacy

Context:

Saquinavir, an HIV protease inhibitor, exhibits significant inter-individual pharmacokinetic variability.
This variability stems from low absorption and extensive hepatic metabolism.
Understanding these factors is crucial for optimizing treatment efficacy.

Purpose:

To evaluate the relevance and evidence level of therapeutic drug monitoring (TDM) for saquinavir in HIV-infected patients.
To determine optimal saquinavir plasma concentrations for virologic response and assess exposure-toxicity relationships.

Summary:

In treatment-naïve patients, undetectable HIV viral load at 48 weeks was associated with saquinavir trough concentrations > 100 ng/mL.
In pre-treated patients, genotypic inhibitory quotient predicted virologic response with a threshold around 40 ng/mL/mutation.
High saquinavir concentrations were linked to increased risk of severe abdominal pain, though no specific threshold was identified.

Impact:

Saquinavir TDM is recommended to optimize virologic response in HIV management.
Evidence from multiple studies, including a randomized trial, supports the utility of saquinavir TDM.
This monitoring can aid clinicians in personalizing saquinavir dosing for improved patient outcomes.