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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Caroline Solas¹, Patrice Muret²,

¹Laboratoire de Pharmacocinétique et Toxicologie, Hôpital de La Timone, Marseille, France.

|July 10, 2016

Summary

This summary is machine-generated.

Therapeutic drug monitoring for atazanavir is recommended. Optimal trough concentrations improve HIV viral load suppression and reduce hyperbilirubinemia risk in patients.

Keywords:

atazanavir level of evidence niveau de preuve suivi thérapeutique pharmacologique therapeutic drug monitoring

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Area of Science:

Pharmacology
Hepatology
Infectious Diseases

Context:

Atazanavir, an HIV protease inhibitor, exhibits significant inter-individual variability due to hepatic metabolism.
Dose-dependent hyperbilirubinemia is a common adverse effect associated with atazanavir therapy.

Purpose:

To evaluate the utility of therapeutic drug monitoring for atazanavir in HIV-infected patients.
To determine optimal atazanavir plasma trough concentrations for virologic response and toxicity management.

Summary:

Higher atazanavir trough concentrations (Cmin >200 ng/mL) are linked to undetectable HIV viral load at 48 weeks in treatment-naïve patients.
A genotypic inhibitory quotient threshold around 200 ng/mL/mutation predicts virologic response in pre-treated patients.
Risk of severe hyperbilirubinemia (Grade 3-4) increases with Cmin >750-800 ng/mL.

Impact:

Therapeutic drug monitoring of atazanavir can optimize treatment outcomes by improving viral suppression.
Monitoring helps prevent severe bilirubin elevations, enhancing patient safety and treatment adherence.
Evidence supports the recommendation for atazanavir therapeutic drug monitoring in clinical practice.