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A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
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Central serous chorioretinopathy in primary hyperaldosteronism
Elon H C van Dijk1, Michiel F Nijhoff2,3, Eiko K de Jong4
1Department of Ophthalmology, Leiden University Medical Center, Department J3-S, PO Box 9600, 2300RC, Leiden, Netherlands.
Summary
Primary hyperaldosteronism (PA) is linked to retinal abnormalities similar to central serous chorioretinopathy (CSC). These findings suggest mineralocorticoid pathways contribute to CSC development, especially in hypertensive patients.
Area of Science:
- Ophthalmology
- Endocrinology
- Cardiology
Background:
- Primary hyperaldosteronism (PA) is a condition characterized by excessive aldosterone secretion.
- Hypertension is a common comorbidity associated with PA.
- Ophthalmological manifestations of PA are not well-established.
Purpose of the Study:
- To investigate and describe the ophthalmological characteristics in patients diagnosed with primary hyperaldosteronism.
- To identify any specific retinal or choroidal abnormalities associated with PA.
Main Methods:
- A cross-sectional study was conducted involving 13 patients with confirmed PA.
- All participants underwent comprehensive ophthalmological examinations, including imaging techniques.
Main Results:
- Two patients (15%) exhibited macular serous subretinal fluid (SRF) on optical coherence tomography.
- One patient had bilateral chronic central serous chorioretinopathy (CSC) with polypoidal choroidal neovasculopathy, successfully treated with photodynamic therapy.
- Retinal pigment epithelium alterations resembling CSC were observed in 38% of patients; mean subfoveal choroidal thickness was 290.2 ± 65.0 μm.
Conclusions:
- Retinal abnormalities suggestive of subclinical CSC are frequently observed in PA patients.
- Mineralocorticoid-mediated pathways likely play a role in the pathogenesis of CSC.
- PA should be considered in the differential diagnosis of CSC, particularly in hypertensive individuals with unknown causes.
Keywords:
Central serous chorioretinopathyCross-sectional studyEplerenoneHyperaldosteronismMineralocorticoid antagonistSpironolactoneMore Related Videos
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