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[Not Available].

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Area of Science:

  • Immunology
  • Pharmacology
  • Reproductive Medicine

Context:

  • Lung transplantation enables women of childbearing age to consider pregnancy.
  • Pregnancy following organ transplantation necessitates specialized therapeutic drug management.
  • Existing data on immunosuppressive drug management during pregnancy is increasing.

Purpose:

  • To describe the case management of drug therapy before and during pregnancy in two post-lung or heart-lung transplant patients.
  • To highlight the importance of teratogenic and fetotoxic drug considerations.
  • To address pharmacokinetic changes during pregnancy.

Summary:

  • This case series details the pre- and peri-pregnancy drug management for two women post-lung or heart-lung transplantation.
  • Management involved careful selection of immunosuppressive drugs and associated therapies, considering fetal and maternal safety.
  • A comprehensive literature review guided the therapeutic drug management to prevent complications.

Impact:

  • Provides insights into managing immunosuppressive therapies in pregnant transplant recipients.
  • Aims to improve maternal and fetal outcomes in this unique patient population.
  • Contributes to the growing body of evidence on pregnancy after solid organ transplantation.