Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

2.0K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel mouse model of combined blast and carbon monoxide-induced brain injury recapitulating coal mine gas explosions.

Experimental neurology·2026
Same author

Aerobic Exercise and Subthreshold Depressive Symptoms in Adolescents: Secondary Analysis of a Randomized Clinical Trial.

JAMA network open·2026
Same author

Time-resolved single-nucleus profiling of inter- and intracellular signaling in optic nerve injury: From the hyperacute phase to the acute phase.

Neural regeneration research·2026
Same author

Astrocytic FDX1 Contributes to Copper Dyshomeostasis-associated Synaptic Dysfunction in Depression and Is Modulated by Exercise.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Intravitreal delivery of NGF-chitosan hydrogel confers retinal ganglion cell protection and visual function recovery in experimental glaucoma.

Bioactive materials·2026
Same author

Repeated exposure to the smell of innate fear, trimethylthiazoline, promotes fear habituation and hippocampal cell proliferation in rats.

Stress (Amsterdam, Netherlands)·2026

Related Experiment Video

Updated: Mar 18, 2026

Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation
04:48

Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation

Published on: April 18, 2025

1.2K

Voluntary Wheel Running Reverses the Decrease in Subventricular Zone Neurogenesis Caused by Corticosterone.

Jada Chia-Di Lee1,2,3, Suk-Yu Yau4, Tatia M C Lee3,5,6

  • 1Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, P.R. China.

Cell Transplantation
|July 10, 2016
PubMed
Summary

Voluntary exercise boosts cell proliferation in the subventricular zone (SVZ), while corticosterone (CORT) suppresses it. Exercise counteracts CORT

Keywords:
Adult neurogenesisCorticosterone (CORT)Subventricular zone (SVZ)Voluntary exerciseWheel running

More Related Videos

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD
06:09

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD

Published on: February 2, 2017

7.2K
A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice
06:59

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice

Published on: April 28, 2022

4.9K

Related Experiment Videos

Last Updated: Mar 18, 2026

Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation
04:48

Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation

Published on: April 18, 2025

1.2K
Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD
06:09

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD

Published on: February 2, 2017

7.2K
A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice
06:59

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice

Published on: April 28, 2022

4.9K

Area of Science:

  • Neuroscience
  • Cell Biology

Background:

  • Adult neurogenesis occurs in the dentate gyrus (DG) and subventricular zone (SVZ).
  • Voluntary exercise enhances DG neurogenesis, while stress (corticosterone/CORT) suppresses it.
  • CORT and exercise effects on SVZ neurogenesis are controversial, and their combined effects are unknown.

Purpose of the Study:

  • To investigate if CORT suppresses SVZ cell proliferation.
  • To determine if voluntary exercise can reverse CORT-induced suppression of SVZ cell proliferation.
  • To examine the cotreatment effects of CORT and voluntary exercise on SVZ cell proliferation and differentiation.

Main Methods:

  • Adult Sprague-Dawley rats were subjected to chronic (4 weeks) corticosterone (CORT) treatment and/or voluntary wheel running.
  • Cell proliferation was assessed using bromodeoxyuridine (BrdU) labeling.
  • Cell differentiation was evaluated by double-labeling BrdU with doublecortin (DCX), a marker for migrating neuroblasts.

Main Results:

  • Voluntary wheel running increased SVZ cell proliferation (BrdU+ cells).
  • CORT treatment decreased SVZ cell proliferation in rats without running.
  • Combined CORT treatment and wheel running maintained SVZ cell proliferation at control levels.
  • Wheel running increased the percentage of BrdU+ cells expressing DCX, indicating enhanced neuroblast migration.
  • CORT treatment decreased the percentage of BrdU+ cells expressing DCX, suggesting suppressed differentiation.
  • Exercise alleviated CORT-induced suppression of cell differentiation in the SVZ.

Conclusions:

  • Chronic CORT administration suppresses cell proliferation and differentiation in the adult rat SVZ.
  • Voluntary wheel running increases SVZ cell proliferation and differentiation.
  • Voluntary exercise can reverse the suppressive effects of CORT on SVZ cell proliferation and differentiation.
  • These findings highlight the potential of exercise as an intervention against stress-induced neurogenesis impairment in the SVZ.