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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Dorrà Dridi¹, Mossadok Ben Attia², Karim Aouam¹

¹Laboratoire de Pharmacologie, Faculté de Médecine, Monastir, Tunisie.

Therapie

|July 10, 2016

Summary

Optimizing corticoid medication timing, considering cortisol

Keywords:

Cortisol asthme nocturne ciclesonide circadian rhythms corticoadrenal corticosteroids corticostéroïdes corticosurrénalienne nocturnal asthma pathologie pathology rythmes circadiens

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Area of Science:

Pharmacology
Endocrinology
Chronobiology

Context:

Corticoids, including cortisol and its derivatives, are vital anti-inflammatory drugs.
Their therapeutic efficacy and side effects are influenced by physiological circadian rhythms.
Optimal drug administration requires understanding these time-dependent effects.

Purpose:

To explore chronotherapeutic optimization of corticoid dosing for enhanced efficacy and safety.
To investigate the application of chronobiology in treating conditions like asthma and adrenal insufficiency.
To highlight the advantages of novel inhaled corticoids, such as ciclesonide, within a chronobiologic framework.

Summary:

Therapeutic use of corticoids presents challenges due to cortisol's physiological roles and circadian rhythms.
Time-related administration significantly impacts both beneficial and adverse effects of corticoids.
Chronotherapeutic optimization improves desirable effects and safety in treating adrenocortical failure, congenital adrenal hyperplasia, and asthma.

Impact:

Knowledge of physiological rhythms enables optimized oral corticoid treatment, particularly for asthma.
A chronobiologic approach, combined with molecule modification and inhalation, offers advanced optimization strategies.
This approach positions inhaled corticoids like ciclesonide favorably for improved patient outcomes.