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Related Experiment Video

Updated: Mar 18, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Ghozlane Lakhoua¹, Sihem El Aidli¹, Ahmed Zaïem¹

¹Centre national de Pharmacovigilance, Tunis, Tunisie.

|July 10, 2016

Summary

This summary is machine-generated.

Two cases of fixed drug eruptions were identified, one triggered by pheniramine and another by loratadine. This highlights potential adverse drug reactions from common antihistamines.

Keywords:

H(1) antihistamines antihistaminique H(1)fixed drug eruption loratadine pheniramine phéniramine érythème pigmenté fixe

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Area of Science:

Pharmacology
Dermatology
Clinical Medicine

Context:

Fixed drug eruptions (FDEs) are localized, recurrent cutaneous reactions to specific medications.
Antihistamines are widely used for allergic conditions, but their potential to induce FDEs requires careful consideration.

Purpose:

To report two distinct cases of fixed drug eruptions.
To identify the causative agents as pheniramine and loratadine.

Summary:

The first case involved a fixed drug eruption attributed to pheniramine, a first-generation antihistamine.
The second case documented a fixed drug eruption associated with loratadine, a second-generation antihistamine.
These cases underscore the variability in drug-induced hypersensitivity reactions.

Impact:

Highlights the importance of considering antihistamines, including both older and newer generations, as potential triggers for fixed drug eruptions.
Contributes to the understanding of adverse drug reactions and informs clinical prescribing practices.
Emphasizes the need for thorough patient history and pharmacovigilance regarding antihistamine use.