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MRI morphologic alterations after liver SBRT : Direct dose correlation with intermodal matching.

Judit Boda-Heggemann1, Ulrike Attenberger2, Johannes Budjan2

  • 1Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer Ufer 1-3, 68167, Mannheim, Germany. judit.boda-heggemann@umm.de.

Strahlentherapie Und Onkologie : Organ Der Deutschen Rontgengesellschaft ... [Et Al]
|July 10, 2016
PubMed
Summary

This study correlates MRI findings with radiation doses in liver tissue after SBRT. Low-dose radiation (38-42 Gy) causes distinct MRI changes in healthy liver tissue, enabling MRI-based dose assessment.

Keywords:
Deep inspiration breath-holdLiver metastasesMagnetic resonance imagingNormal tissue reactionsStereotactic body radiation therapy

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Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Stereotactic body radiation therapy (SBRT) can cause morphologic and histopathologic changes in liver tissue.
  • Assessing these changes is crucial for understanding radiation effects and optimizing treatment.

Purpose of the Study:

  • To analyze the correlation between MRI-observed morphologic alterations and radiation doses in healthy liver tissue following SBRT.
  • To evaluate the potential for MRI-based dose-effect correlations in liver tissue.

Main Methods:

  • Retrospective analysis of MRI data from 24 patients treated with SBRT for liver metastases.
  • Intermodal matching of MRI images to planning CT and dose distributions.
  • Conversion of radiation doses to Equivalent Uniform Dose in 2 Gy fractions (EQD2) using various alpha/beta values.

Main Results:

  • Characteristic MRI morphologic alterations, including T1 and T2 intensity changes, were observed in the beam path.
  • These changes correlated with specific isodose lines, indicating radiation-induced effects.
  • Doses of 38-42 Gy (EQD2, α/β = 2-3) were found to induce these characteristic MRI alterations in healthy liver tissue.

Conclusions:

  • Deformable image matching enabled direct spatial and dosimetric correlation of SBRT-induced liver tissue changes.
  • Specific MRI morphologic alterations in healthy liver tissue are indicative of radiation doses as low as 38-42 Gy (EQD2, α/β = 2-3).
  • These findings support the potential for using MRI to assess radiation dose-effect relationships in liver tissue post-SBRT.